Die Bedeutung von Körper und Bewegung für die kindliche Resilienz. Psychomotorik als Beitrag zum Aufbau des Selbstwertgefühls bei sozial ängstlichen Kindern. Eine empirische Erhebung in Kasuistiken.

In der vorliegenden Dissertation steht die Frage nach der Bedeutung von Körper und Bewegung für die kindliche Resilienz im Fokus. Den theoretischen Zugang zur Bearbeitung der Fragestellung bilden die Konstrukte Entwicklung und Gesundheit. Diese prägen die aktuelle Fachdiskussion zur Lebensspanne Kindheit entscheidend mit. Kindheit wird in der vorliegenden Arbeit als soziale Konstruktion verstanden, das sich als integrales Element moderner Gesellschaften in sozialgeschichtlichen und politisch-institutionellen Zusammenhängen konstituiert. Dies impliziert die Annahme, dass Kinder in gleichem Maße von gesellschaftlichen Entwicklungen betroffen sind, wie Erwachsene. Kindheiten sind demnach stets in ihrem aktuellen Kontext und im Zuge des vielfach diskutierten Wandels der Kindheit im Spannungsfeld aktueller gesellschaftlicher Entwicklung zu interpretieren. Entwicklung wird in dieser Arbeit als subjektive Sinn-Konstruktion, als dynamischer, lebenslanger und interaktiver Prozess verstanden. Ausgehend von einem kontextualistisch geprägten Entwicklungsbegriff, gestaltet das Kind Entwicklungsprozesse auf der Grundlage sich wechselseitig beeinflussender Person-Umwelt-Interaktionsprozesse als Produzent aktiv handelnd mit (Entwicklung als Handlung im Kontext. Für die Bewältigung altersspezifisch anstehender Entwicklungsaufgaben rückt auf der Grundlage aktueller Erkenntnisse aus der Resilienzforschung sowie gesundheitstheoretischer Aspekte die Frage nach den Ressourcen in den Vordergrund, die das Kind gegen risikoreiche Einflüsse resilient macht. Mit Bezugnahme auf die salutogenetische Perspektive von Antonovsky (1997) wird dem Aufbau des Kohärenzsinns als gesundheitsrelevante Ressource eine besondere Bedeutung im Rahmen kindlicher Entwicklungsprozesse beigemessen. Hier stellte sich die Frage, wie diese Vorüberlegungen für sozial ängstliche Kinder mit einem gering ausgeprägten Selbstwertgefühl zu interpretieren sind. Soziale Ängstlichkeit wird in diesem Zusammenhang als Problemlage angenommen, die sich als Bewertungsangst in der Besorgnis und Aufgeregtheit angesichts von sozialen Situationen im Sinne einer Selbstwertbedrohung widerspiegelt. Wenn sozial ängstliches Verhalten bei Kindern zur Problemlage wird, wirkt sich dies negativ auf den Kohärenzsinn und somit negativ auf den optimalen Einsatz von Widerstandsressourcen aus, was in der Konsequenz ein erhöhtes Entwicklungs- und Gesundheitsrisiko zur Folge haben kann. Dies führt dazu, dass Ressourcen zur Kompensation der bestehenden Problemlage eingesetzt werden, anstatt diese für die Auseinandersetzung mit und Bewältigung von anstehenden Entwicklungsaufgaben zu nutzen. Dem Aufbau eines positiven Selbstwertgefühls als kindbezogene Ressource kommt hier eine besondere Bedeutung zu. Dieses stellt in Orientierung an die Überlegungen von Renate Zimmer die evaluative Komponente des Selbstkonzeptes dar und hebt den engen Zusammenhang zwischen dem Selbstwertgefühl, dem Selbstbild als kognitive und der Selbstwirksamkeit als motivationale Komponente hervor. Indem das Kind in der aktiven Auseinandersetzung selbst wirksam tätig ist, versteht es eigene spielerische Handlungen bei der Konstruktion der eigenen sozialen Wirklichkeit. Dabei können zunehmend Handlungskompetenzen aufgebaut werden. Das Kind erlebt sein Tun als sinnvoll und subjektiv bedeutsam. Eine solche kompetenzstrukturierende Perspektive findet sich sowohl im handlungsorientierten Ansatz von Fischer (2006) als auch im Konzept der Psychomotorischen Entwicklungstheorie von Krus (2004) wieder, da das Handeln als Entwicklungshandeln interpretiert wird. Demnach wird der Dialogcharakter der Bewegung, das Entwicklungshandeln als Realitätskonstruktion und Kompetenzgewinn sowie ein Begreifen der Handlungskompetenz als Zusammenspiel kognitiver, sozialer und emotionaler Elemente akzentuiert und den untrennbaren Zusammenhang von Wahrnehmung, Bewegung, Selbstkonzept und Körpererfahrungen hervorhebt. Da die motivationale Komponente insbesondere für sozial ängstliche Kinder mit einem gering ausgeprägten Selbstwertgefühl von Bedeutung ist, bieten sich zirzensische Inhalte in der Psychomotorik für den Aufbau eines positiven Selbstwertgefühls sehr gut an. Für die empirische Überprüfung der oben benannten Vorannahmen ist eine mehrperspektivische Betrachtungsweise erforderlich. In dieser Arbeit wird ein einzelfallbezogener Zugang gewählt, bei dem sozial ängstliche Kinder einzelfallspezifisch in ihren kontextuellen Bezügen betrachtet werden. Die Datenanalyse erfolgt ebenfalls mehrperspektivisch auf den Betrachtungsebenen "Kind", "Kontext" und "Projekt". Dabei bildete die Einzelfallanalyse in Form der kindbezogenen Themenbildung und die Grounded Theory im Sinne der kontextbezogenen Theoriebildung den Ausgangspunkt für eine Prä-Post-Analyse. Projektbezogen stellte die zielorientierte Dokumentation den Ausgangspunkt dar, um verlaufsbezogene Veränderungen einzelfallspezifisch aufzuzeigen

The influence of basaltic islands on the oceanic REE distribution: A case study from the tropical South Pacific

The Rare Earth Elements (REEs) have been widely used to investigate marine biogeochemical processes as well as the sources and mixing of water masses. However, there are still important uncertainties about the global aqueous REE cycle with respect to the contributions of highly reactive basaltic minerals originating from volcanic islands and the role of Submarine Groundwater Discharge (SGD). Here we present dissolved REE concentrations obtained from waters at the island-ocean interface (including SGD, river, lagoon and coastal waters) from the island of Tahiti and from three detailed open ocean profiles on the Manihiki Plateau (including neodymium (Nd) isotope compositions), which are located in ocean currents downstream of Tahiti. Tahitian fresh waters have highly variable REE concentrations that likely result from variable water–rock interaction and removal by secondary minerals. In contrast to studies on other islands, the SGD samples do not exhibit elevated REE concentrations but have distinctive REE distributions and Y/Ho ratios. The basaltic Tahitian rocks impart a REE pattern to the waters characterized by a middle REE enrichment, with a peak at europium similar to groundwaters and coastal waters of other volcanic islands in the Pacific. However, the basaltic island REE characteristics (with the exception of elevated Y/Ho ratios) are lost during transport to the Manihiki Plateau within surface waters that also exhibit highly radiogenic Nd isotope signatures. Our new data demonstrate that REE concentrations are enriched in Tahitian coastal water, but without multidimensional sampling, basaltic island Nd flux estimates range over orders of magnitude from relatively small to globally significant. Antarctic Intermediate Water (AAIW) loses its characteristic Nd isotopic signature (-6 to-9) around the Manihiki Plateau as a consequence of mixing with South Equatorial Pacific Intermediate Water (SEqPIW), which shows more positive values (-1 to -2). However, an additional Nd input/exchange along the pathway of AAIW, eventually originating from the volcanic Society, Tuamotu and Tubuai Islands (including Tahiti), is indicated by an offset from the mixing array of AAIW and SEqPIW to more radiogenic Nd isotope compositions

The ISOARC project: From source to sink – Monitoring the isotopic fingerprints of Arctic moisture

In order to constrain the isotopic fingerprint of the Arctic hydrological cycle, a new generation of Picarro water isotope analyzers using CRDS (cavity ringdown spectroscopy) is used to monitor the isotopic composition of atmospheric water vapour at different sites. Since July 2015, within the ISOARC project water vapour stable isotopes (HDO and H218O; d excess) have been continuously measured: (1) on-board Polarstern (as oceanic moisture source) and (2) at Samoylov Island in the Lena Delta in northern Siberia (72°22’ N, 126°29’E) as sink in the water cycle. On Polarstern the water vapour has been sampled during ship cruise at 30 meters above sea surface. In addition to these water vapour measurements, ocean surface waters have been sampled on a daily basis and were later analysed in the laboratory for its water isotope composition. Data comprises two summer Arctic campaigns in 2015 and 2016 covering a large region of the Arctic Ocean, including the North Pole in September 2015. In the central and eastern Arctic Ocean, a large area of complete sea ice cover revealed a strong impact on the moisture above the ice cap under very cold conditions. On Samoylov Island, water vapour has been sampled from an inlet situated at 5 m height above the Siberian tundra typical for the Lena Delta. Isotope measurements were compared with meteorological and surface data collected throughout the year in the Lena delta, as well as to data from other sites such as Svalbard or Iceland run by partner institutes. We were able to measure the isotope composition to low humidity levels in Arctic winter. This water vapour network is a new approach into the understanding of the Arctic hydrological cycle at the regional scale. A first model-data comparison of our measurements with simulation results by the isotope-enabled atmospheric general circulation model ECHAM5-wiso have depicted relevant model biases in the Arctic realm, particularly close to the sea ice covered areas

Chemically induced hypoxia by dimethyloxalylglycine (dmog)-loaded nanoporous silica nanoparticles supports endothelial tube formation by sustained vegf release from adipose tissue-derived stem cells

Inadequate vascularization leading to insufficient oxygen and nutrient supply in deeper layers of bioartificial tissues remains a limitation in current tissue engineering approaches to which prevascularization offers a promising solution. Hypoxia triggering pre-vascularization by enhanced vascular endothelial growth factor (VEGF) expression can be induced chemically by dimethyloxalylglycine (DMOG). Nanoporous silica nanoparticles (NPSNPs, or mesoporous silica nanoparticles, MSNs) enable sustained delivery of molecules and potentially release DMOG allowing a durable capillarization of a construct. Here we evaluated the effects of soluble DMOG and DMOG-loaded NPSNPs on VEGF secretion of adipose tissue-derived stem cells (ASC) and on tube formation by human umbilical vein endothelial cells (HUVEC)-ASC co-cultures. Repeated doses of 100 mM and 500 mM soluble DMOG on ASC resulted in 3- to 7-fold increased VEGF levels on day 9 (P<0.0001). Same doses of DMOG-NPSNPs enhanced VEGF secretion 7.7-fold (P<0.0001) which could be maintained until day 12 with 500 mM DMOG-NPSNPs. In fibrin-based tube formation assays, 100 mM DMOG-NPSNPs had inhibitory effects whereas 50 mM significantly increased tube length, area and number of junctions transiently for 4 days. Thus, DMOG-NPSNPs supported endothelial tube formation by upregulated VEGF secretion from ASC and thus display a promising tool for prevascularization of tissue-engineered constructs. Further studies will evaluate their effect in hydrogels under perfusion

Isotopic exchange on the diurnal scale between near-surface snow and lower atmospheric water vapor at Kohnen station, East Antarctica

Quantifying the magnitude of post-depositional processes affecting the isotopic composition of surface snow is essential for a more accurate interpretation of ice core data. To achieve this, high temporal resolution measurements of both lower atmospheric water vapor and surface snow iso- topic composition are required. This study presents contin- uous measurements of water vapor isotopes performed in East Antarctica (Kohnen station) from December 2013 to January 2014 using a laser spectrometer. Observations have been compared with the outputs of two atmospheric gen- eral circulation models (AGCMs) equipped with water va- por isotopes: ECHAM5-wiso and LMDZ5Aiso. During our monitoring period, the signals in the 2 m air temperature T , humidity mixing ratio q and both water vapor isotopes δD and δ18O are dominated by the presence of diurnal cycles. Both AGCMs simulate similar diurnal cycles with a mean amplitude 30 to 70 % lower than observed, possibly due to an incorrect simulation of the surface energy balance and the boundary layer dynamics. In parallel, snow surface samples were collected each hour over 35 h, with a sampling depth of 2–5 mm. A diurnal cycle in the isotopic composition of the snow surface is observed in phase with the water vapor, reaching a peak-to-peak amplitude of 3 ‰ for δD over 24 h (compared to 36 ‰ for δD in the water vapor). A simple box model treated as a closed system has been developed to study the exchange of water molecules between an air and a snow reservoir. In the vapor, the box model simulations show too much isotopic depletion compared to the observations. Mix- ing with other sources (advection, free troposphere) has to be included in order to fit the observations. At the snow surface, the simulated isotopic values are close to the observations with a snow reservoir of ∼ 5 mm depth (range of the snow sample depth). Our analysis suggests that fractionation oc- curs during sublimation and that vapor–snow exchanges can no longer be considered insignificant for the isotopic compo- sition of near-surface snow in polar regions

Moisture origin as a driver of temporal variabilities of the water vapour isotopic composition in the Lena River Delta, Siberia

In the context of the Arctic amplification of climate change affecting the regional atmospheric hydrological cycle, it is crucial to characterize the present-day moisture sources of the Arctic. The isotopic composition is an important tool to enhance our understanding of the drivers of the hydrological cycle due to the different molecular characteristics of water stable isotopes during phase change. This study introduces 2 years of continuous in situ water vapour and precipitation isotopic observations conducted since July 2015 in the eastern Siberian Lena delta at the research station on Samoylov Island. The vapour isotopic signals are dominated by variations at seasonal and synoptic timescales. Diurnal variations of the vapour isotopic signals are masked by synoptic variations, indicating low variations of the amplitude of local sources at the diurnal scale in winter, summer and autumn. Low-amplitude diurnal variations in spring may indicate exchange of moisture between the atmosphere and the snow-covered surface. Moisture source diagnostics based on semi-Lagrangian backward trajectories reveal that different air mass origins have contrasting contributions to the moisture budget of the Lena delta region. At the seasonal scale, the distance from the net moisture sources to the arrival site strongly varies. During the coldest months, no contribution from local secondary evaporation is observed. Variations of the vapour isotopic composition during the cold season on the synoptic timescale are strongly related to moisture source regions and variations in atmospheric transport: warm and isotopically enriched moist air is linked to fast transport from the Atlantic sector, while dry and cold air with isotopically depleted moisture is generally associated with air masses moving slowly over northern Eurasia

Alertness Training Increases Visual Processing Speed in Healthy Older Adults

In this study, we investigated whether alertness training in healthy older adults increases visual processing speed (VPS) and whether functional connectivity in the cingulo-opercular network predicts training gain. Using the theory of visual attention, we derived quantitative estimates of VPS before and after training. In Study 1, 75 healthy older adults participated in alertness training, active-control training, or no training (n = 25 each). A significant Group × Session interaction indicated an increase in VPS in the alertness-training group but not in the control group, despite VPS not differing significantly between groups before training. In Study 2, 29 healthy older adults underwent resting-state functional MRI and then participated in alertness training. Pretraining functional connectivity in the cingulo-opercular network correlated with the individual training-induced change in VPS. In conclusion, results indicate that alertness training improves visual processing in older adults and that functional connectivity in the cingulo-opercular network provides a neural marker for predicting individual training gain

Safe Brain Tumor Resection Does not Depend on Surgery Alone - Role of Hemodynamics

Aim of this study was to determine if perioperative hemodynamics have an impact on perioperative infarct volume and patients' prognosis. 201 cases with surgery for a newly diagnosed or recurrent glioblastoma were retrospectively analyzed. Clinical data and perioperative hemodynamic parameters, blood tests and time of surgery were recorded. Postoperative infarct volume was quantitatively assessed by semiautomatic segmentation. Mean diastolic blood pressure (dBP) during surgery (rho -0.239, 95% CI -0.11 - -0.367, p = 0.017), liquid balance (rho 0.236, 95% CI 0.1-0.373, p = 0.017) and mean arterial pressure (MAP) during surgery (rho -0.206, 95% CI -0.07 - -0.34, p = 0.041) showed significant correlation to infarct volume. A rank regression model including also age and recurrent surgery as possible confounders revealed mean intraoperative dBP, liquid balance and length of surgery as independent factors for infarct volume. Univariate survival analysis showed mean intraoperative dBP and MAP as significant prognostic factors, length of surgery also remained as significant prognostic factor in a multivariate model. Perioperative close anesthesiologic monitoring of blood pressure and liquid balance is of high significance during brain tumor surgery and should be performed to prevent or minimize perioperative infarctions and to prolong survival

Retrospective Analysis of Radiological Recurrence Patterns in Glioblastoma, Their Prognostic Value And Association to Postoperative Infarct Volume

Recent studies suggested that postoperative hypoxia might trigger invasive tumor growth, resulting in diffuse/multifocal recurrence patterns. Aim of this study was to analyze distinct recurrence patterns and their association to postoperative infarct volume and outcome. 526 consecutive glioblastoma patients were analyzed, of which 129 met our inclusion criteria: initial tumor diagnosis, surgery, postoperative diffusion-weighted imaging and tumor recurrence during follow-up. Distinct patterns of contrast-enhancement at initial diagnosis and at first tumor recurrence (multifocal growth/progression, contact to dura/ventricle, ependymal spread, local/distant recurrence) were recorded by two blinded neuroradiologists. The association of radiological patterns to survival and postoperative infarct volume was analyzed by uni-/multivariate survival analyses and binary logistic regression analysis. With increasing postoperative infarct volume, patients were significantly more likely to develop multifocal recurrence, recurrence with contact to ventricle and contact to dura. Patients with multifocal recurrence (Hazard Ratio (HR) 1.99, P = 0.010) had significantly shorter OS, patients with recurrent tumor with contact to ventricle (HR 1.85, P = 0.036), ependymal spread (HR 2.97, P = 0.004) and distant recurrence (HR 1.75, P = 0.019) significantly shorter post-progression survival in multivariate analyses including well-established prognostic factors like age, Karnofsky Performance Score (KPS), therapy, extent of resection and patterns of primary tumors. Postoperative infarct volume might initiate hypoxia-mediated aggressive tumor growth resulting in multifocal and diffuse recurrence patterns and impaired survival

Microparticles and crystal microstructure in polar ice sheets

The pollution input in polar ice sheets in Greenland and Antarctica is of atmospheric aeolian origin, just as all natural non-ice impurities as well. They thus provide potential information on the evolution of the atmospheric share of pollutants in the ocean. Aerosols found in ice are transported with atmospheric circulation and wind patterns and are deposited e.g. with precipitating snow. The impurity content in this so-called meteoric ice is relatively low compared to many other natural materials such as rocks (ppb to ppm range). The reason is that most aerosols in the atmosphere have been removed by fall-out or precipitation during transport from the impurities’ sources to the remote ice sheet. Non-ice constituents in polar ice cores have been studied in the last decades mainly for reconstructions of past atmospheric aerosol concentrations, with respect to questions conceding the global climate change. The fastest and easiest analytical way is chemical analysis of the melted water from ice cores. However despite the tiny concentrations, the interactions with and effects of impurities in the solid ice influence the physical properties of the material as a whole: e.g. electric as well as dielectric response and, in particular, mechanical behaviour thus “softness” of the material seems to be strongly controlled by impurities. Smaller concentrations of impurities (up to a few ‰) do soften the material as a whole, while larger concentrations of particles harden it, depending on the type of impurities of course. The underlying processes are partly hypothesised for decades, but not yet proven or understood satisfactorily as the quest for ppb to ppm concentrations in solid matrix material is a search for a “needle in a haystack”. To improve the data basis regarding the in-situ form of incorporation and spatial distribution of impurities in ice we used micro-cryo-Raman spectroscopy to identify the location, phase and composition of micrometer-sized inclusions in natural ice samples (NEEM ice core from Greenland and EPICA-DML ice core from Antarctica). The combination of Raman results with ice-microsctructure measurements and complementary impurity data provided by the standard analytical methods (IC, CFA, and DEP) allows for a more interdisciplinary approach interconnecting ice core chemistry and ice core physics. While the samples originating from interglacial times were dominated by sulfate salts—mainly gypsum, sodium sulfate (possibly thenardite) and iron–potassium sulfate (likely jarosite)—the glacial ice contained high numbers of mineral dust particles—in particular quartz, mica, feldspar, anatase, hematite and carbonaceous particles (black carbon). We cannot confirm cumulation of impurities in the grain boundary network as reported by other studies, neither micro-particles being dragged by migrating grain boundaries nor in form of liquid veins in triple junctions. We argue that mixing of impurities on the millimeter scale and chemical reactions are facilitated by the deforming ice matrix. Refs.: doi: 10.5194/tc-11-1075-2017 doi: 10.3389/feart.2019.00020 https://www.humboldt-foundation.de/web/trilateral-jagfos-2019.html http://www.nasonline.org/programs/kavli-frontiers-of-science/past-symposia/2019-jagfos.html Invited poster